pentobarbital will lower the extent or result of acalabrutinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will lower the extent or outcome of ethotoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Observe.pentobarbital will lower the extent or impact of artemether/lumefantrine by impact